Anime Last Stand Alchemy Essence is the core evolution material in Update 66’s Fullmetal theme, and you’ll be spending most of your grind chasing it. This guide explains exactly what Alchemy Essence is, where it drops, how much you need per unit, and how to plan efficient farming runs so your evolutions stay on schedule.
What is Anime Last Stand Alchemy Essence?
Alchemy Essence is the mandatory resource for evolving every new unit released in Update 66. It is consumed directly in evolution recipes (for example, when evolving Short Alchemist or Armored Alchemist). Because all six newcomers use the same item, Essence quickly becomes the bottleneck for progression, making smart planning more valuable than banner luck.
How to Get Anime Last Stand Alchemy Essence
There’s only one source: Laboratory 5 – Legend Stage. The stage has a 100% drop chance, awarding 20–35 Alchemy Essence per clear. It’s intentionally tough and solo-only, so consistency depends on bringing a strong endgame team capable of clearing without fail. If your loadout can’t survive the entire run, your evolution timeline stalls, since no other activity drops Essence.
A few planning notes based on the fixed source:
Treat Lab 5 – Legend like a daily route, not a one-off burst.
Aim for clean, repeatable clears rather than risky speed attempts; every failure costs time with no alternative farm.
Because it’s solo-only, schedule sessions when you can focus fully to reduce mistakes.
How much Alchemy Essence do you need?
Per unit: about 200–250 Essence
All six Update 66 units: roughly 1,300 Essence total
Translating that into runs:
At the minimum 20 Essence per clear, ~65 clears reach the ~1,300 total.
Using a realistic average of 27 per run, you’re looking at ~48 clears for the full set.
Per unit, budget 8–10 runs on a 27-average, or 10–13 runs if your drops hover near the minimum.
These numbers are your blueprint. Decide whether you’re evolving one showcase unit immediately or batching runs to cover several evolutions in a row.
Farming tips and route planning
You don’t need tricks here; you need reliability. Use the numbers above to build a straightforward schedule.
Prioritize your first evolve. Pick the unit that impacts your account the most and funnel Essence there first. This keeps your roster improving while you continue farming for the rest.
Block your sessions. If you plan for five clears per session, you’ll finish a single 200–250-Essence evolve in two sessions on average, and the full six-unit plan in around ten sessions at steady pace.
Track your average. If your runs trend closer to 27 than 20, you can confidently trim a few sessions from the plan. If you’re scraping minimums, extend your timeline accordingly.
Optimize for consistency. Lab 5 – Legend is hard and solo-only. Bring the endgame team you rely on, not experimental builds. The “best way” to evolve units is simply the way you don’t fail, since every clear pays Essence.
Stagger materials. Since Essence is the shared choke point, gather any side materials for your target evolves in parallel so you can evolve immediately when your Essence total hits the threshold.
Using Alchemy Essence efficiently
Alchemy Essence feeds straight into Update 66 evolutions. Spend it only on your planned targets to avoid delays. If your goal is a full set of six, set milestones after each evolve so you always know whether to keep stacking for the next 200–250 or pause to test your upgraded unit before continuing the grind.
Final Thoughts
Anime Last Stand Alchemy Essence is the unavoidable gate for Update 66 evolutions. Farm Laboratory 5 – Legend for a guaranteed 20–35 Essence per run, expect 200–250 per unit and ~1,300 for all six, and plan on ~48 clears at a 27-per-run average. Keep your Lab 5 clears consistent with an endgame team, prioritize the first evolve that meaningfully boosts your account, and track your totals so every session pushes you toward the next upgrade. With a simple, disciplined route, you’ll keep evolutions rolling without wasting time or Essence.